Last updated: 2021-05-20

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Published subset of adult hypothalamic data (Nature + Cell datasets) in UMAP (cells similarity) space

Version Author Date
e644d13 EugOT 2021-05-20
acde8ba EugOT 2021-05-19

Density of expression for MC-R gene family in UMAP space

Version Author Date
e644d13 EugOT 2021-05-20
acde8ba EugOT 2021-05-19

Zoom into area of highest density of Mc4r expressing cells in UMAP space (PNe of PVN)

Version Author Date
e644d13 EugOT 2021-05-20
acde8ba EugOT 2021-05-19

Age dynamic

Version Author Date
e644d13 EugOT 2021-05-20
acde8ba EugOT 2021-05-19
Selected genes are within intersection of top 0.05 correlation with Trh and top 0.1 correlation with Trh and within intersection of bottom 0.05 correlation with Trh and bottom 0.1 correlation with Trh; genes with same or higher percent of expressing cells as Mc4r
term Mc4r Trh
Dgkg 0.35 0.43
Lin37 0.33 0.28
Cluh 0.28 0.26
1700086L19Rik 0.28 0.28
Vstm2l 0.27 0.33
Polr1c 0.27 0.25
Pkib 0.26 0.26
Pura 0.25 0.31
Brinp3 0.25 0.43
Dgat2 0.25 0.35
Ccdc181 0.25 0.24
Sel1l3 0.23 0.30
Slc1a4 0.23 0.31
Saxo2 0.22 0.27
Fam73a 0.22 0.24
Tmem59l 0.21 0.24
Fh1 0.21 0.44
Cntn4 0.21 0.45
Cntnap3 0.20 0.52
Lgi1 0.20 0.23
Dgkb 0.20 0.46
Arhgap26 0.20 0.35
Purb 0.20 0.30
Hdhd2 0.19 0.33
Nudt9 0.19 0.51
Mdga2 0.19 0.36
Csgalnact1 0.19 0.39
Csmd3 0.19 0.30
Nfu1 0.19 0.27
Tcta 0.19 0.29
Nfia 0.18 0.26
Mbnl2 0.18 0.56
Brk1 0.18 0.24
Mrpl55 0.18 0.37
Htr4 0.18 0.32
Mlip 0.18 0.27
Smdt1 0.18 0.33
Ostm1 0.18 0.23
Snrk 0.18 0.31
Fam107a 0.18 0.26
Fam183b 0.18 0.29
Ubb 0.18 0.51
Prkg1 0.18 0.53
Cycs 0.17 0.46
Psmg4 0.17 0.26
Chchd10 0.17 0.39
Pld3 0.17 0.27
Rasa3 0.17 0.28
St6galnac6 0.17 0.25
Prdx5 0.17 0.26
Tmem132b 0.16 0.49
Stard7 0.16 0.26
2010300C02Rik 0.16 0.34
Coq7 0.16 0.30
Pdzrn4 0.16 0.36
2310039H08Rik 0.15 0.29
Mkrn1 0.15 0.23
Ptprn 0.15 0.26
Hmgn3 0.15 0.24
Wrb 0.15 0.25
Rpp25l 0.15 0.36
Cuta 0.15 0.24
Mpc1 0.15 0.28
Ddit3 0.15 0.23
Slc10a6 0.15 0.35
Rab27a 0.15 0.25
mt-Nd6 0.15 0.28
Gpr101 0.14 0.29
Oxct1 0.14 0.26
Kars 0.14 0.25
Greb1l 0.14 0.33
Flywch1 0.14 0.32
Gpx4 0.14 0.50
Cyb561 0.14 0.27
Tbc1d20 0.14 0.23
Necab2 0.14 0.34
Dync1i1 0.14 0.46
Atp5sl 0.14 0.26
Rxrg 0.14 0.28
Mrpl27 0.14 0.28
Naa20 0.14 0.24
Tmx4 0.14 0.29
Sfmbt2 0.13 0.24
Pnkd 0.13 0.24
Nsmf 0.13 0.26
Dlg1 0.13 0.26
Syt5 0.13 0.29
Ndufa7 0.13 0.51
Rogdi 0.13 0.26
Ndufb9 0.13 0.46
Ppargc1a 0.13 0.29
Htr7 0.13 0.34
Gm4876 0.13 0.29
Cdh13 0.13 0.24
Ndufa8 0.13 0.32
Psma5 0.13 0.31
Mpc2 0.13 0.32
Efr3a 0.12 0.25
Pcbd1 0.12 0.26
Macrod1 0.12 0.27
Mrfap1 0.12 0.38
Tef 0.12 0.23
Phb 0.12 0.26
Rundc1 0.12 0.24
Kcnc2 0.12 0.31
Phyhip 0.12 0.28
Dtd1 0.12 0.25
Gfra4 0.12 0.23
Mdh2 0.12 0.48
Bex1 0.12 0.32
Zkscan16 0.12 0.35
Ppp1r17 0.12 0.37
Gdi1 0.12 0.27
Mdh1 0.12 0.27
2010107E04Rik 0.12 0.37
Ckmt1 0.12 0.28
Eno2 0.12 0.34
Mrps15 0.12 0.27
Rtn1 0.11 0.25
Mzt1 0.11 0.26
Srm 0.11 0.24
Gstp2 0.11 0.31
Thrb 0.11 0.26
Vps4a 0.11 0.24
Slc22a17 0.11 0.25
Pacrg 0.11 0.28
Asic2 0.11 0.35
Riiad1 0.11 0.26
Atp6v1f 0.11 0.40
Gm42418 -0.06 -0.16
Tcf12 -0.06 -0.15
Epha6 -0.06 -0.15
Ssbp2 -0.06 -0.14
Kctd16 -0.06 -0.16
Hmbox1 -0.06 -0.17
Ythdf2 -0.06 -0.14
Hnrnpk -0.06 -0.24
Clasp1 -0.06 -0.15
Zfp804a -0.06 -0.15
Sox11 -0.06 -0.25
Dlgap3 -0.06 -0.11
mt-Co3 -0.07 -0.18
Ebf3 -0.07 -0.12
Nova1 -0.07 -0.14
Zc3h7b -0.07 -0.11
mt-Nd3 -0.07 -0.15
Lmnb1 -0.07 -0.14
Actr3 -0.07 -0.14
Elavl2 -0.07 -0.21
Med13l -0.07 -0.11
Srrm2 -0.07 -0.20
Psmb6 -0.07 -0.14
Ogt -0.07 -0.12
Scg2 -0.07 -0.14
Rbm3 -0.07 -0.12
Ctsb -0.07 -0.11
Gm26917 -0.07 -0.34
Ctnna2 -0.07 -0.22
Fnbp1l -0.07 -0.19
Resp18 -0.07 -0.15
Sox4 -0.07 -0.12
Ubc -0.07 -0.12
Ina -0.08 -0.12
Stmn1 -0.08 -0.14
Btbd9 -0.08 -0.15
Cdc37 -0.08 -0.11
Kcnh8 -0.08 -0.15
Hnrnpab -0.08 -0.12
Hn1 -0.08 -0.18
Trio -0.08 -0.14
Zcchc11 -0.08 -0.15
Cep78 -0.08 -0.12
Rasa1 -0.08 -0.12
Npas3 -0.08 -0.15
Shank1 -0.08 -0.15
Plppr3 -0.08 -0.17
Runx1t1 -0.08 -0.23
Dip2b -0.08 -0.13
Tnrc6c -0.08 -0.11
Nrp1 -0.08 -0.13
Dusp8 -0.08 -0.14
Astn2 -0.08 -0.18
Fign -0.08 -0.16
Ddx5 -0.08 -0.24
Smarce1 -0.08 -0.14
Gm26848 -0.08 -0.11
Rbm42 -0.08 -0.12
Pds5a -0.08 -0.16
Pde3b -0.08 -0.12
Wdr70 -0.08 -0.12
Zfand5 -0.08 -0.12
Strip1 -0.08 -0.11
Tmpo -0.08 -0.11
Phc2 -0.08 -0.13
Eif2s2 -0.08 -0.12
Slc1a2 -0.09 -0.12
Rad21 -0.09 -0.11
Tubb5 -0.09 -0.34
Kalrn -0.09 -0.29
Grik3 -0.09 -0.12
1700025G04Rik -0.09 -0.11
Snf8 -0.09 -0.11
Nkain3 -0.09 -0.22
Ubxn7 -0.09 -0.12
Sox5 -0.09 -0.15
E130308A19Rik -0.09 -0.17
Zfp462 -0.09 -0.11
Slc38a10 -0.09 -0.12
Zswim6 -0.09 -0.14
Inpp4b -0.09 -0.12
Alk -0.09 -0.16
Mapk6 -0.09 -0.11
Zfp704 -0.10 -0.14
Fgf13 -0.10 -0.11
Stag2 -0.10 -0.11
Zfp207 -0.10 -0.13
Klhl29 -0.10 -0.11
Anp32a -0.10 -0.14
Dock7 -0.10 -0.18
Map4 -0.10 -0.16
Rab11a -0.10 -0.13
Wnk1 -0.10 -0.13
Kmt2e -0.10 -0.14
Srgap3 -0.10 -0.12
Slc8a1 -0.10 -0.14
Zfp57 -0.10 -0.14
Dpp10 -0.11 -0.13
Arid2 -0.11 -0.14
Tcf20 -0.11 -0.18
mt-Nd1 -0.11 -0.19
Hmgcr -0.11 -0.12
Arid1a -0.11 -0.12
Dzip1 -0.11 -0.13
Klf12 -0.11 -0.15
Kcnh7 -0.11 -0.15
Tmem163 -0.11 -0.14
Erbb4 -0.12 -0.16
Il1rapl1 -0.12 -0.18
Fam19a2 -0.12 -0.20
Gpc6 -0.12 -0.20
Dlk1 -0.12 -0.26
Lingo2 -0.12 -0.16
Auts2 -0.12 -0.38
Robo1 -0.13 -0.26
D630045J12Rik -0.13 -0.14
Celf2 -0.13 -0.23
Ncam2 -0.13 -0.30
Rbfox1 -0.13 -0.16
Ccser1 -0.14 -0.23
Hnrnpc -0.14 -0.20
Slit2 -0.15 -0.25
Sntg1 -0.15 -0.19
Kcnip1 -0.16 -0.18
Unc5d -0.17 -0.24
Elavl3 -0.18 -0.14
Xkr4 -0.18 -0.18
Cadm2 -0.18 -0.32

Version Author Date
acde8ba EugOT 2021-05-19

Version Author Date
acde8ba EugOT 2021-05-19

Gene Combinations

Version Author Date
acde8ba EugOT 2021-05-19

Version Author Date
acde8ba EugOT 2021-05-19

Version Author Date
acde8ba EugOT 2021-05-19

Version Author Date
acde8ba EugOT 2021-05-19

R version 4.1.0 (2021-05-18)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: Ubuntu 20.10

Matrix products: default
BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.10.so

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
 [3] LC_TIME=de_AT.UTF-8        LC_COLLATE=en_US.UTF-8    
 [5] LC_MONETARY=de_AT.UTF-8    LC_MESSAGES=en_US.UTF-8   
 [7] LC_PAPER=de_AT.UTF-8       LC_NAME=C                 
 [9] LC_ADDRESS=C               LC_TELEPHONE=C            
[11] LC_MEASUREMENT=de_AT.UTF-8 LC_IDENTIFICATION=C       

attached base packages:
[1] stats     graphics  grDevices datasets  utils     methods   base     

other attached packages:
 [1] Nebulosa_1.2.0        patchwork_1.1.1       UpSetR_1.4.0         
 [4] SeuratDisk_0.0.0.9019 SeuratWrappers_0.3.0  SeuratObject_4.0.1   
 [7] Seurat_4.0.1          kableExtra_1.3.4      future_1.21.0        
[10] magrittr_2.0.1        forcats_0.5.1         stringr_1.4.0        
[13] dplyr_1.0.6           purrr_0.3.4           readr_1.4.0          
[16] tidyr_1.1.3           tibble_3.1.2          ggplot2_3.3.3        
[19] tidyverse_1.3.1       here_1.0.1            workflowr_1.6.2      

loaded via a namespace (and not attached):
  [1] utf8_1.2.1                  reticulate_1.20            
  [3] ks_1.12.0                   tidyselect_1.1.1           
  [5] htmlwidgets_1.5.3           grid_4.1.0                 
  [7] Rtsne_0.15                  munsell_0.5.0              
  [9] codetools_0.2-17            ica_1.0-2                  
 [11] miniUI_0.1.1.1              withr_2.4.2                
 [13] colorspace_2.0-1            Biobase_2.52.0             
 [15] corrr_0.4.3                 highr_0.9                  
 [17] knitr_1.33                  rstudioapi_0.13            
 [19] stats4_4.1.0                SingleCellExperiment_1.14.0
 [21] ROCR_1.0-11                 tensor_1.5                 
 [23] listenv_0.8.0               labeling_0.4.2             
 [25] MatrixGenerics_1.4.0        git2r_0.28.0               
 [27] GenomeInfoDbData_1.2.6      polyclip_1.10-0            
 [29] farver_2.1.0                bit64_4.0.5                
 [31] rprojroot_2.0.2             parallelly_1.25.0          
 [33] vctrs_0.3.8                 generics_0.1.0             
 [35] xfun_0.23                   R6_2.5.0                   
 [37] GenomeInfoDb_1.28.0         rsvd_1.0.5                 
 [39] hdf5r_1.3.3                 bitops_1.0-7               
 [41] spatstat.utils_2.1-0        DelayedArray_0.18.0        
 [43] assertthat_0.2.1            promises_1.2.0.1           
 [45] scales_1.1.1                gtable_0.3.0               
 [47] globals_0.14.0              goftest_1.2-2              
 [49] rlang_0.4.11                systemfonts_1.0.2          
 [51] splines_4.1.0               lazyeval_0.2.2             
 [53] spatstat.geom_2.1-0         broom_0.7.6                
 [55] BiocManager_1.30.15         yaml_2.2.1                 
 [57] reshape2_1.4.4              abind_1.4-5                
 [59] modelr_0.1.8                backports_1.2.1            
 [61] httpuv_1.6.1                tools_4.1.0                
 [63] ellipsis_0.3.2              spatstat.core_2.1-2        
 [65] jquerylib_0.1.4             RColorBrewer_1.1-2         
 [67] BiocGenerics_0.38.0         ggridges_0.5.3             
 [69] Rcpp_1.0.6                  plyr_1.8.6                 
 [71] zlibbioc_1.38.0             RCurl_1.98-1.3             
 [73] rpart_4.1-15                deldir_0.2-10              
 [75] pbapply_1.4-3               cowplot_1.1.1              
 [77] S4Vectors_0.30.0            zoo_1.8-9                  
 [79] SummarizedExperiment_1.22.0 haven_2.4.1                
 [81] ggrepel_0.9.1               cluster_2.1.2              
 [83] fs_1.5.0                    data.table_1.14.0          
 [85] scattermore_0.7             lmtest_0.9-38              
 [87] reprex_2.0.0                RANN_2.6.1                 
 [89] mvtnorm_1.1-1               whisker_0.4                
 [91] fitdistrplus_1.1-3          matrixStats_0.58.0         
 [93] hms_1.1.0                   mime_0.10                  
 [95] evaluate_0.14               xtable_1.8-4               
 [97] mclust_5.4.7                readxl_1.3.1               
 [99] IRanges_2.26.0              gridExtra_2.3              
[101] compiler_4.1.0              KernSmooth_2.23-20         
[103] crayon_1.4.1                htmltools_0.5.1.1          
[105] mgcv_1.8-35                 later_1.2.0                
[107] lubridate_1.7.10            DBI_1.1.1                  
[109] dbplyr_2.1.1                MASS_7.3-54                
[111] Matrix_1.3-3                cli_2.5.0                  
[113] parallel_4.1.0              igraph_1.2.6               
[115] GenomicRanges_1.44.0        pkgconfig_2.0.3            
[117] plotly_4.9.3                spatstat.sparse_2.0-0      
[119] xml2_1.3.2                  svglite_2.0.0              
[121] bslib_0.2.5.1               webshot_0.5.2              
[123] XVector_0.32.0              rvest_1.0.0                
[125] digest_0.6.27               sctransform_0.3.2          
[127] RcppAnnoy_0.0.18            spatstat.data_2.1-0        
[129] rmarkdown_2.8               cellranger_1.1.0           
[131] leiden_0.3.7                uwot_0.1.10                
[133] shiny_1.6.0                 lifecycle_1.0.0            
[135] nlme_3.1-152                jsonlite_1.7.2             
[137] viridisLite_0.4.0           fansi_0.4.2                
[139] pillar_1.6.1                lattice_0.20-44            
[141] fastmap_1.1.0               httr_1.4.2                 
[143] survival_3.2-11             glue_1.4.2                 
[145] remotes_2.3.0               png_0.1-7                  
[147] bit_4.0.4                   stringi_1.6.2              
[149] sass_0.4.0                  renv_0.13.2                
[151] irlba_2.3.3                 future.apply_1.7.0